| CYP2C19基因多态性对药物代谢影响的研究进展 |
| |
| 引用本文： | 彭净,刘卫. CYP2C19基因多态性对药物代谢影响的研究进展[J]. 药学实践杂志, 2015, 33(6): 508-512 |
| |
| 作者姓名： | 彭净 刘卫 |
| |
| 作者单位： | 解放军88医院, 山东 泰安 271000;济宁医学院附属医院, 山东 济宁 272000,解放军88医院, 山东 泰安 271000 |
| |
| 基金项目： | 山东省药学会奥赛康中青年临床药师资助项目(No.sdpa-ask-2013-02) |
| |
| 摘 要： | 药物代谢和相互作用的差异与CYP的单核苷酸基因多态性有关。综述CYP2C19基因多态性对质子泵抑制剂、抗真菌药伏立康唑、抗血小板药氯吡格雷的代谢和药物相互作用的影响,以期为个体化用药提供参考。
|
| 关 键 词： | CYP2C19 基因多态性 质子泵抑制剂 伏立康唑 氯吡格雷 |
| 收稿时间： | 2014-05-16 |
| 修稿时间： | 2015-01-20 |
Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism |
| |
| PENG Jing and LIU Wei. Research progress in the effect of CYP2C19 gene polymorphisms on drug metabolism[J]. The Journal of Pharmaceutical Practice, 2015, 33(6): 508-512 |
| |
| Authors: | PENG Jing and LIU Wei |
| |
| Affiliation: | No. 88 Hospital of PLA, Taian 271000, China;Affiliated Hospital of Jining Medical University, Ji'ning 272000, China and No. 88 Hospital of PLA, Taian 271000, China |
| |
| Abstract: | Drug metabolism and drug-drug interactions were associated with the single nucleotide polymorphisms of CYP. The relationship between CYP2C19 polymorphisms and metabolism as well as interactions of proton pump inhibitors, voriconazole and clopidogrel were reviewed to provide evidence for personalized medication. |
| |
| Keywords: | CYP2C19 polymorphism proton pump inhibitor voriconazole clopidogrel |
|
| 点击此处可从《药学实践杂志》浏览原始摘要信息 |
|
点击此处可从《药学实践杂志》下载全文 |
