亲水性软性角膜接触镜辅助治疗内眼手术后持续性角膜上皮病变

目的探讨亲水性软性角膜接触镜治疗内眼术后各种角膜上皮病变的疗效和安全性。设计回顾性病例分析。研究对象36例（36眼）各种内眼手术后角膜上皮病变迁延不愈的患者，其中大泡性角膜病变5例，非大泡性角膜病变31例。方法对上述患者适当处理角膜病灶后，配戴软性角膜接触镜，并调整眼部用药，一旦角膜上皮愈合即摘除软镜；同一软镜持续配戴不得超过3周，否则更换新软镜。随诊6个月观察患者角膜愈合情况。主要指标角膜上皮愈合、刺激症状缓解及并发症情况。结果35例（97．22％）患者眼部刺激症状在3天内明显好转。至随诊6个月，30例（83．33％）完全缓解，6例（16．67％）明显缓解；30例（86．11％）视力明显提高。全部患者未出现继发感染等并发症，非大泡性角膜病变的患者在3周内角膜病变痊愈、症状消失，摘除软镜；大泡性角膜病变患者中3例10周内摘除软镜，2例观察至6个月仍需配戴。结论亲水性软性角膜接触镜促进内眼术后各种角膜上皮病变愈合的效果显著，同时有效缓解各种伴随的眼部刺激症状，是安全有效的辅助治疗方法。

Application of hydrogel soft contact lens to the treatment of persistence corneal epitheliopathy after intraocular surgery

Objective To investigate the efficacy and safety of hydrogel soft contact lens （HSCL） for persistence corneal epitheliopathy after intraocular surgery. Design Retrospective case series. Participants 36 patients （36 eyes） with bullous keratopathy （n=5） or other keratopatby （n=31） including corneal erosion, epithelium missing, and dendritic keratopathy after intraocular surgery, which failed to medicine treatment 2 weeks ago. Method All patients were fitted with HSCL after suitable processing of the corneal foci. The lenses were removed immediately as long as the keratopathy recovered. A new lens was replaced after 3 weeks if still needed. Main Outcome Measures Changes of keratopathy, pain relief and complications. Result 35 patients （97.22%） fitted with HSCL were very comfort within 3 days. At the follow-up of 6 months, 30 patients （83,33%） achieved complete remission of keratopathy, 6 patients （16.67%） remarkable remission. 30 patients （86.11%） had vision increase. All of the non-bullous keratopathy recovered within 3 weeks, while the lenses were fitted much longer in bullous keratopathy. No other lens-related complications appeared. Conclusion The application of hydrogel soft contact lens to persistence corneal epitheliopathy after intraocular surgery is safe, effective, and practical.