Small Round Cell Tumors of Bone |
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| Affiliation: | 1. Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China;2. Department of Pathology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China;3. Cangzhou Medical College, Cangzhou, Hebei 061001, China;1. Pathology Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil;2. International Research Center, AC Camargo Cancer Center, São Paulo-SP, Brazil;3. Head and Neck Surgery Department, Faculty of Medical Sciences/UNICAMP, Campinas-SP, Brazil;4. Oral Pathology Department, Piracicaba Dental School/UNICAMP, Piracicaba-SP, Brazil;5. Head and Neck Surgery Department, AC Camargo Cancer Center, São Paulo-SP, Brazil;6. Department of Genetics and Evolutionary Biology, Institute of Biosciences, USP, São Paulo-SP, Brazil;1. Department of Cardiac, Thoracic and Vascular Science, University of Padua Medical School, Padua, Italy;2. Department of Medicine, University of Padua Medical School, Padua, Italy |
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| Abstract: | Diagnosing small round cell tumors (SCRTs) can be a difficult task for pathologists due to overlapping clinicopathologic features. This review highlights the clinical, radiographic, histologic, immunohistochemical, and genetic features of the most common SRCTs involving bone with an emphasis on differential diagnosis. SRCTs are a heterogeneous group of neoplasms characterized by poorly differentiated cells with small, blue, round nuclei and scant cytoplasm. They can occur as primary tumors in bone or soft tissue. |
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