Inhibitory effect of miR-184 on the potential of proliferation and invasion in human glioma and breast cancer cells in vitro
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| Authors: | Ren Feng Lei Dong |
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| Institution: | 1.Department of Medical Administration, Tianjin Huanhu Hospital, Children’s Healthcare of Atlanta, Tianjin 300060, China;2.Department of Pediatrics, Division of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, GA 30322, USA |
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| Abstract: | MiR-184 was an important suppressor to tumor cells proliferation and invasion and some studies show that it was down-regulated in aggressive human tumor cells and a potential tumor therapy target through expression of miR-184 results in reduced tumor cell aggressiveness. In this study, miR-184 showed an inhibitive activity of glioma U87MG cell line and breast cancer MCF-7 cell line in proliferation and invasion by MTS and transwell assay. We found that the miR-184 also could arrest cell cycle and adhesion by up-regulating the expression of p53 and p21 and activity of caspase-3/8, suppressing the expression of SND1, MMP-2/9, CD44 and activity of AKT/NF-κB pathway. The results showed that miR-184 could be a potential target for glioma and breast cancer treatment. |
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| Keywords: | miR-184 proliferation invasion |
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