肺超声联合血清NT-proBNP、sFlt-1对急性呼吸窘迫综合征患者病情严重程度及预后评估价值

目的探讨肺超声联合血清氨基末端脑钠肽前体(NT-proBNP)、可溶性血管内皮生长因子受体(sFlt-1)对急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者病情严重程度及预后评估价值。方法选取2018年4月-2020年10月本院收治的ARDS患者138例。按照氧合指数(OI)将ARDS患者分为重度组(OI≤100 mmHg,n=58)、中度组(100 mmHg

Evaluation value of severity and prognosis of Lung ultrasound combined with serum NT-proBNP and sFlt-1 on acute respiratory distress syndrome in patient

Objective To explore the evaluation value of lung ultrasound combined with serum N-terminal pro-brain natriuretic peptide(NT-proBNP) and soluble vascular endothelial growth factor receptor(sFlt-1) in evaluating the severity and prognosis of acute respiratory distress syndrome(ARDS). Methods Totally 138 ARDS patients were enrolled as the research subjects who treated in our hospital from April 2018 to October 2020. The subjects were classified into severe group (OI≤100 mmHg, 58 cases), moderate group (100 mmHgResults Difference were statistically different in LUS, serum NT-proBNP, and sFlt-1 levels among three groups (P<0.05), which in the severe group were highest in groups (P<0.05), followed by moderate group, and finally the mild group (all P<0.05). Totally 41 (41/138, 29.71%) cases with poor prognosis involved in 138 ARDS patients, Logistic multivariate analysis showed that influencing factors for ARDS patient prognosis were the length of stay in intensive care unit(ICU), LUS, NT-proBNP level, and sFlt-1 level (OR=3.943, 3.736, 3.337, 4.289, P<0.05), the ROC curve showed that the prognostic AUC of the combination of the three on diagnosis of ARDS was 0.896, which was higher than the AUC of LUS, NT-proBNP, and sFlt-1 alone (0.751, 0.844, 0.773). Conclusion For ARDS patients, the combination of the three can assess the severity, and has a high diagnostic efficiency for the prognosis; therefore, it can be used as an important clinical reference index.