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Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature |
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| Institution: | 1. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;2. Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden;3. Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden;4. Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden |
| Abstract: | Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain. |
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