| 心脑舒通胶囊对急性脑缺血再灌注大鼠皮质单胺类神经递质的影响 |
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| 引用本文： | 陶冶,张允岭,刘超,王新祥,刘雪梅,郑宏,闫妍.心脑舒通胶囊对急性脑缺血再灌注大鼠皮质单胺类神经递质的影响[J].天津中医药,2008,25(6):503-505. |
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| 作者姓名： | 陶冶 张允岭 刘超 王新祥 刘雪梅 郑宏 闫妍 |
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| 作者单位： | 北京中医药大学东方医院,北京,100078 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)
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教育部新世纪优秀人才支持汁划
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| 摘 要： | 目的]观察活血化瘀通络中药--心脑舒通胶囊对急性脑缺血再灌注大鼠皮质单胺类神经递质的影响.方法]健康雄性sD大鼠42只,动物随机分为假手术组、模型组和心脑舒通组,心脑舒通组灌胃给予心脑舒通混悬液,假手术组和模型组给予等量蒸馏水.术前3d开始连续灌胃给药(11.57mg/g),1次/d,至术后1d共4d.采用线栓法致大鼠大脑中动脉阻塞建立急性脑缺血再灌注模型,缺血1.5 h再灌注24 h后断头取脑.常规苏木-伊红(HE)染色观察患侧皮质病理学改变,高效液相色谱法测定患侧皮质单胺类神经递质含量变化.结果]心脑舒通胶囊能明显减轻急性脑缺血再灌注大鼠皮质病理形态改变,显著降低异常升高的肾上腺素(E)、多巴胺(DA)、5-羟色胺(5-HT)的含量.结论]心脑舒通胶囊可减轻脑缺血损伤程度.其作用机制可能与改善单胺类神经递质的紊乱有关.
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| 关 键 词： | 急惟脑缺血再灌注 病理形态改变 单胺类神经递质 心脑舒通胶囊 |
| 收稿时间： | 6/6/2008 12:00:00 AM |
Effect of Xinnaoshutong capsule on monoamine neurotransmitter in Cortex in rats with cerebral ischemia and reperfusion |
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| TAO Ye,ZHANG Yun-ling,LIU Chao.Effect of Xinnaoshutong capsule on monoamine neurotransmitter in Cortex in rats with cerebral ischemia and reperfusion[J].Tianjin Journal of Traditional Chin Medicine,2008,25(6):503-505. |
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| Authors: | TAO Ye ZHANG Yun-ling LIU Chao |
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| Institution: | TAO Ye,ZHANG Yun-ling,LIU Chao,et al (The Dongfang Hospital of Beijing University of TCM,Beijing 100078,China) |
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| Abstract: | Objective] To research the effect of Xinnaoshutong(dredging heart and brain) capsule (XNST), a Chinese medicine with effect of activating blood circulation,removing stasis and dredging collateral), on monoamine neurotransmitter in rats with cerebral ischemia and reperfusion injury. Methods] Forty-two male SD rats were randomly divided into sham,model,XNST treatment group. Acute cere- bral ischemia and reperfusion was induced with thread occlusion technique inducing middle cerebral artery occlusion in rats... |
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| Keywords: | acute cerebral ischemia and reperfusion pathomorphology monoamine neurotransmitter Xinnaoshutong capsule |
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