血浆同型半胱氨酸与动脉粥样硬化及脑梗死相关研究

目的:探讨血浆同型半胱氨酸水平与动脉粥样硬化及脑梗死的关系。方法:选择动脉粥样硬化性脑梗死140例患者为脑梗死组,选择同期年龄、性别相匹配的健康体检者100例为对照组。根据颈动脉多普勒彩色超声检查结果将脑梗死组及对照组再进行分组;脑梗死有斑块组和对照有斑块组合称为斑块组,脑梗死无斑块组和对照无斑块组合称为无斑块组。采用高效液相色谱法测定血浆同型半胱氨酸水平;应用颈动脉多普勒彩色超声检查患者颈动脉内膜中层厚度。结果:动脉粥样硬化性脑梗死患者血浆同型半胱氨酸、颈动脉内膜中层厚度均较对照组明显增高(P<0.05);脑梗死有斑块组血浆同型半胱氨酸、内膜中层厚度水平均高于脑梗死无斑块组(P<0.05)。结论:血浆同型半胱氨酸水平与动脉粥样硬化病变有密切关系,可能是动脉粥样硬化性脑梗死的一种危险因素。

Relation of plasma homocysteine to cerebral infarction and cerebral atherosclerosis

Objective:To investigate the relationship among plasma homocysteine,atherosclerosis and cerebral infarction.Methods:One hundred and forty patients were chosen for the cerebral infarction group and one hundred healthy people for the control group.According to the results of carotid Doppler ultrasonography,these patients were redivided into two subgroups.The cerebral infarction with carotid atherosclerotic plaque and the control with carotid atherosclerotic plaque were called plaque groups.The cerebral infarction without carotic atherosclerotic plaque and the control without carotid atherosclerotic plaque were called non-plaque groups.The levels of plasma homocysteine were measured.All groups were examined for the changes of carotid intimal-medial thickness by carotid duplex ultrasonography scanning.Results:The plasma level of homocysteine was significantly higher in the group of atherothrombotic cerebral infarction than that in the control group(P<0.05);The plasma level of homocysteine was significantly higher in the plaque group than that in the non-plaque group(P<0.05)。 Conclusions:Plasma homocysteine level has a close correlation with carotid atherosclerotic plaque,and homocysteine and the high level of homocysteine may be a risk factor of cerebral infarction.