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Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses |
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| Authors: | Gazzolo Diego Bruschettini Matteo Corvino Valentina Lituania Mario Sarli Rossana Bruschettini Pierluigi Michetti Fabrizio |
| Affiliation: | a Department of Paediatrics, Giannina Gaslini Children's University Hospital, I-16147, Genoa, Italy b Institute of Anatomy, Catholic University, Largo Francesco Vito, 1, I-00168, Rome, Italy c Department of Obstetrics and Gynaecology, Giannina Gaslini Children's University Hospital, I-16147, Genoa, Italy d Department of Obstetrics and Gynaecology, Genoa University Hospital, I-16121, Genoa, Italy |
| Abstract: | Background: The human chromosome 21 has been shown to contain the gene for the β subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21. Methods: Measurements of S100B in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100). Results: Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83±0.21 μg/l) than in controls (0.51±0.22 μg/l) (p<0.05). Conclusion: The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool. |
| Keywords: | S100B protein Foetus Brain maturation Amniotic fluid Trisomy-21 |
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