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| 北京市石景山区健康人群甲流抗体水平及疫苗免疫效果 | |
| 引用本文： | 郭舫茹,吴劲,杨咸枝,王建斌,孙凤梅,李东艳,康桂枝,井慧泉,李素艳.北京市石景山区健康人群甲流抗体水平及疫苗免疫效果[J].首都公共卫生,2011,5(3):98-101. |
| 作者姓名： | 郭舫茹 吴劲 杨咸枝 王建斌 孙凤梅 李东艳 康桂枝 井慧泉 李素艳 |
| 作者单位： | 1. 北京市石景山区疾病预防控制中心,100043 2. 清华大学玉泉医院 3. 北京工人疗养院 4. 北京市八宝山社区卫生服务中心 5. 北京市八大处中医门诊部 6. 北京市老山社区卫生服务中心 7. 首钢矿山医院 |
| 摘 要： | 目的了解北京市石景山区健康人群甲型H1N1流感抗体水平及疫苗的免疫效果。方法随机选取10个年龄组共236人作为人群抗体水平监测对象,其中83人作为疫苗免疫效果评估对象,共采集319份静脉血采用血凝抑制试验测定H1抗体。结果健康人群中抗体阳性率为31.36%,几何平均滴度(GMT)为1∶17.22,各年龄组间差异有统计学意义(χ2=57.43,P<0.001;F=9.12,P<0.001),20～59岁组水平最低,职业分布与年龄分布相一致。监测免疫后人群83人,抗体阳性率为95.18%,GMT为1∶184.41,显著高于免疫前水平(χ2=70.58,P<0.001;F=17.59,P<0.001)。结论石景山区人群已具有一定的甲型H1N1流感保护性抗体水平,甲型H1N1流感疫苗具有良好的流行病学保护效果。 |
| 关 键 词： | 甲型H1N1流感 血凝抑制试验 几何平均滴度 疫苗效果监测 |
Serum leve1 of antibodies against influenza A (H1N1) at baseline and after vaccination among healthy people in Shijingshan district of Beijing in 2009 |
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| GUO Fang-ru,WU Jin,YANG Xian-zhi,WANG Jian-bin,SUN Feng-mei,LI Dong-yan,KANG Gui-zhi,JING Hui-quan,LI Su-yan.Serum leve1 of antibodies against influenza A (H1N1) at baseline and after vaccination among healthy people in Shijingshan district of Beijing in 2009[J].Capital Journal of Public Health,2011,5(3):98-101. | |
| Authors: | GUO Fang-ru WU Jin YANG Xian-zhi WANG Jian-bin SUN Feng-mei LI Dong-yan KANG Gui-zhi JING Hui-quan LI Su-yan |
| Institution: | GUO Fang-ru,WU Jin,YANG Xian-zhi,WANG Jian-bin,SUN Feng-mei,LI Dong-yan,KANG Gui-zhi,JING Hui-quan,LI Su-yan (Shijingshan District Center for Disease Control and Prevention,Beijing 100043,China) |
| Abstract: | Objective To understand serum level of antibody against influenza A (H1N1) virus at baseline and after vaccination among healthy people in Shijingshan district of Beijing to provide scientific basis for further promotion of its vaccination. Methods A total of 236 people at various age groups were selected for the study, 83 for evaluating immunological effects after vaccination. In total, 319 serum specimens were collected to detect hemagglutination-inhibition (HI) antibody against 2009 influenza A (H1N1) vi... |
| Keywords: | Influenza A (H1N1) Hemagglutination-inhibition assays Geometric mean titer (GMT) Surveillance immunological effect vaccine |
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