慢性肾功能衰竭多项血清炎症因子水平分析

目的：探讨慢性肾功能衰竭多项血清炎症因子水平的变化规律。方法：选取2008年10月~2010年12月于我院进行治疗的68例慢性肾功能衰竭患者为研究对象,将其设为观察组,同时选取同期68例健康体检者为对照组,将两组患者的血清TNF-α、CRP、IL-6、IL-8、IL-10水平进行检测、统计及比较。结果：观察组的血清TNF-α、CRP、IL-6、IL-8、IL-10水平（38.76±3.20）pg/ml、（24.78±2.24）mg/L、（86.52±13.25）pg/ml、（102.46±14.50）pg/ml、（79.37±5.26）ng/ml]均高于对照组（6.57±2.17）pg/ml、（3.49±1.25）mg/L、（11.32±5.98）pg/ml、（24.17±10.98）pg/ml、（18.14±4.24）ng/ml],经比较,差异均有统计学意义（均P〈0.05）;观察组不同分期间患者血清TNF-α、CRP、IL-6、IL-8、IL-10水平比较,差异有统计学意义（P〈0.05）,且随着分期增加,各因子的表达水平也增加。结论：血清TNF-α、CRP、IL-6、IL-8、IL-10水平可作为判断慢性肾功能衰竭疾病严重程度的指标。

Study on the variation of various serum inflammatory factors in chronic renal failure

Objective：To explore the variation of various serum inflammatory factors in chronic renal failure.Methods：68 patients with chronic renal failure in our hospital from October 2008 to December 2010 were selected as research object（observation group）,and 68 cases of healthy people at the same time were selected as control group,then the serum TNF-α,CRP,IL-6,IL-8 and IL-10 levels of two groups were detected and compared.Results：The serum TNF-α,CRP,IL-6,IL-8 and IL-10 levels of observation group （38.76±3.20）pg/ml,（24.78±2.24）mg/L,（86.52±13.25）pg/ml,（102.46±14.50）pg/ml,（79.37±5.26）ng/ml]were all higher than those of control group （6.57±2.17）pg/ml,（3.49±1.25）mg/L,（11.32±5.98）pg/ml,（24.17± 10.98）pg/ml,（18.14±4.24）ng/ml],and there were all significant differences（all P0.05）.The serum TNF-α,CRP,IL-6,IL-8 and IL-10 levels of different stages of the observation group were compared,and there was a significant difference（P0.05）.As the increasing of the stage,the expression levels of the factors were increased.Conclusion：The various serum inflam-matory factors in chronic renal failure show higher levels,and it shows positive correlation to disease severity.