α-硫辛酸、溴吡斯的明联合治疗糖尿病神经源性膀胱疗效观察

目的：观察α-硫辛酸、溴吡斯的明联合治疗糖尿病神经源性膀胱的临床疗效。方法：40例2型糖尿病神经源性膀胱患者,给予α-硫辛酸、溴吡斯的明联合治疗2周,比较治疗前后B超膀胱残余尿量的变化。结果：治疗后B超测定的膀胱残余尿量（40±8）ml较治疗前（205±11）ml有明显减少（t=6.677,P〈0.001）;停药4周后B超测定的膀胱残余尿量（20±5）ml,较治疗前（205±11）ml有明显减少（t=7.033,P〈0.001）。结论：α-硫辛酸、溴吡斯的明联合治疗糖尿病神经源性膀胱,可以明显改善尿潴留,有较好的临床疗效。

Clinical observation on Lipoic Acid and Pyridostigmine Bromide in treating diabetic neurogenic bladder

Objective：To observe the efficacy of Lipoic Acid and Pyridostigmine Bromide in treating diabetic neurogenic bladder.Methods：40 patients with type 2 diabetes and diabetic neurogenic bladder were treated with Lipoic Acid and Pyridostigmine Bromide for two weeks,and the postvoiding residue of bladder measured by ultragonogram were compared before and after therapy.Results：The postvoiding residue of bladder after therapy（40±8） ml were significantly decreased than those before therapy（205±11） ml（t=6.677,P0.001）.The postvoiding residue of bladder four weeks after drug discontinuance（20±5） ml were significantly decreased than those before therapy（205±11） ml（t=7.033,P0.001）.Conclusion：Lipoic Acid and Pyridostigmine Bromide can significantly improve the postvoiding residue of bladder in patients with diabetic neurogenic bladder.