脂质体肺部给药的应用进展

脂质体肺部给药作为一种非侵入性给药形式,可以使药物局部定量化,实现肺部疾病的直接靶向,免除肝脏首过效应,生物利用度高,同时通过脂质双层的延时作用,避免频繁给药。本文介绍了脂质体肺部给药的相关优越性、给药方式以及国内外有关脂质体作为抗炎抗感染药物、抗氧化药物、抗哮喘药物、抗肿瘤药物、抗血栓药物等的载体,通过肺部给药的形式发挥相关作用的研究与进展。

Application and Development of Liposome Formulation in Pulmonary Delivery

The liposome-mediated pulmonary drug delivery as a non-invasive administration,makes drugs located at the site of action to treat pulmonary diseases directly,reduces extrapulmonary side-effects,avoids the hepatic first pass effect,increases the bioavailability and avoids frequent administration as the double-layer of the liposome can increase the retention-time.The related advantage of the liposome-mediated pulmonary drug delivery and the way of administration are mainly introduced in this review.We also su...