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| 盐酸法舒地尔治疗慢性肺源性心脏病心力衰竭患者的疗效观察 | |
| 引用本文： | 周锡国,赵立波,张光勇.盐酸法舒地尔治疗慢性肺源性心脏病心力衰竭患者的疗效观察[J].中国医药导报,2011,8(15):80-82. |
| 作者姓名： | 周锡国 赵立波 张光勇 |
| 作者单位： | 1. 重庆市南岸区中医院内科,重庆,400060 2. 重庆市第三人民医院神经科,重庆,400014 3. 重庆市南岸区妇幼保健院内科,重庆,400066 |
| 摘 要： | 目的：观察盐酸法舒地尔治疗慢性肺源性心脏病（chronic cor pulmonale,CCP）心力衰竭（heart failure,HF）的疗效,寻找治疗CCP HF的新药物。方法：将100例CCP HF患者随机分为治疗组和对照组,每组各50例,分别静脉滴注盐酸法舒地尔30 mg,每12小时1次和酚妥拉明10 mg,每日1次,治疗14 d,观察两组临床疗效,并作血液流变学和血气分析。结果：治疗组的总有效率（88%）高于对照组的（72%）,治疗组的显效率（70%）高于对照组的（54%）,差异均有统计学意义（均P〈0.05）。两组动脉血氧分压、血氧饱和度及二氧化碳分压指标均有明显改善（P〈0.05）,但治疗组指标改善均高于对照组（P〈0.05）。治疗组的全血黏度高切、低切、血浆黏度、纤维蛋白原指标改善（P〈0.05）。无严重不良反应,无效率、死亡率差异无统计学意义（P〉0.05）。结论：盐酸法舒地尔治疗CCP HF能够提高临床疗效,改善血气指标,降低血液黏度,没有导致严重副作用,可以考虑将盐酸法舒地尔试用于治疗CCP HF。 |
| 关 键 词： | 盐酸法舒地尔 慢性肺源性心脏病 心力衰竭 疗效 |
Therapeutic effects of Fasudil Hydrochloride on treating heart failure of chronic cor pulmonale |
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| ZHOU Xiguo,ZHAO Libo,ZHANG Guangyong.Therapeutic effects of Fasudil Hydrochloride on treating heart failure of chronic cor pulmonale[J].China Medical Herald,2011,8(15):80-82. | |
| Authors: | ZHOU Xiguo ZHAO Libo ZHANG Guangyong |
| Institution: | ZHOU Xiguo1,ZHAO Libo2,ZHANG Guangyong3 1.Medical Department,Nan'an Distract Hospital of Traditional Chinese Medicine of Chongqing City,400060,China,2.Department of Neurology,the Third People's Hospital of Chongqing City,400014,3.Medical Department,Nan'an Distract Maternal and Child Health Hospital of Chongqing City,400066 |
| Abstract: | Objective:To observe the therapeutic effects of Fasudil Hydrochloride on treating heart failure(HF) of chronic cor pulmonale(CCP).Methods:100 patients with HF of CP were divided into two groups randomly and equally.The treatment group was treated with Fasudil Hydrochloride 30 mg,q12 h,ivgtt,for 14 days,control group was treated with Phentolamine 10 mg,qd,ivgtt,for 14 days.Therapeutic effects,blood gas analysis and hemorheology parameters were got before and after treatment in both groups.Results:The total e... |
| Keywords: | Fasudil Hydrochloride Chronic Cor Pulmonale Heart failure Therapeutic effect |
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