红霉素和糖皮质激素联合治疗持续高热的肺炎支原体肺炎的疗效

目的：观察联合应用红霉素和糖皮质激素治疗持续高热的肺炎支原体肺炎的疗效。方法：将支原体肺炎急性期持续高热患儿44例随机分为两组,治疗组给予红霉素20～30 mg/（kg.d）连续7～10 d,糖皮质激素静滴3～5 d,对照组给予阿奇霉素10 mg/（kg.d）,连续5 d。两组均给予退热、平喘、雾化等对症治疗。对比观察两组退热时间、病情变化、C-反应蛋白（CRP）的变化及住院时间。结果：治疗组发热持续时间为（2.27±1.12）d,对照组为（3.54±1.68）d,差异有统计学意义（t=2.953,P〈0.01）;治疗组重症肺炎发生率为9.1%,低于对照组40.9%（χ2=4.364,P〈0.05）;治疗组住院时间治疗组为（8.45±3.17）d,明显少于对照组（11.09±3.17）d（t=2.981,P〈0.01）;CRP水平随病情好转显著下降,治疗后治疗组CRP水平为（5.24±7.60）mg/L,低于对照组（11.65±10.48）mg/L（t=2.324,P〈0.01）。结论：联合应用红霉素和糖皮质激素治疗持续高热的肺炎支原体肺炎疗效肯定,可有效地缓解临床症状,减少向重症肺炎发展,缩短发热时间,从而减少住院天数。

Effectiveness of erythromycin and glucocorticoid in the treatment of mycoplasma pneumoniae pneumonia with continuous high fever in children

Objective： To observe the therapeutic effect of erythromycin and glucocorticoid in the treatment of children diagnosed with mycoplasma pneumoniae pneumonia with continuous high fever.Methods： 44 patients were divided into 2 groups randomly.Patients in treatment group were treated with erythromycin 20-30 mg/（kg·d） for 7-10 days and glucocorticoid（3～5 days）;and the control group were treated with azithromycin 10 mg/（kg·d） for 5 days.Two groups were given antifebrile,relieving asthma,atomization treatment et al.The level of serum c-reactive protein（CRP）,duration of fever,changing of the clinical symptoms and hospital time of two groups were observed.Results：There were significant differences between the two groups in duration of fever（2.27±1.12） d vs（3.54±1.68） d]（t=2.953,P0.01）,incidence rate of severe pneumonia（9.1% vs 40.9%,χ2=4.364,P0.05） and hospital time （8.45±3.17） d vs（11.09±3.17） d,（t=2.981,P0.01）].The level of serum CRP decreased with the restore of disease and CRP level was lower than control group （5.24±7.60） mg/L vs（11.65±10.48） mg/L,t=2.324,P0.01].Conclusion： The therapeutic effect of erythromycin and glucocorticoid in treating mycoplasma pneumoniae pneumonia with continuous high fever is sure.It can effectively alleviate the clinical symptoms,reduce the risk to develop severe pneumonia,decrease the duration of fever,and reduce the hospital time.