| 对乙酰氨基酚肝毒性机理及药物干预靶点 |
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| 引用本文： | 汪 倩,徐瑞娟,杨 劲. 对乙酰氨基酚肝毒性机理及药物干预靶点[J]. 药学与临床研究, 2011, 19(3): 247-252 |
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| 作者姓名： | 汪 倩 徐瑞娟 杨 劲 |
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| 作者单位： | 中国药科大学药代中心,南京,210009 |
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| 摘 要： | 由于对乙酰氨基酚用药普遍性和广泛性,其肝毒性问题日益引起人们的关注。本文介绍对乙酰氨基酚肝脏代谢、转运以及与Keap1-Nrf2通路有关的生理性调控机制,阐述对乙酰氨基酚的肝毒性机理,包括代谢损伤和氧化应激损伤两大理论。并以此为基础从吸收、代谢、转运等方面对其治疗靶点及干预药物加以综述。其中,Keap1-Nrf2抗氧化解毒通路和转运蛋白环节与对乙酰氨基酚肝毒性关系的研究在近几年逐渐增多,有望发现新的治疗靶点和对乙酰氨基酚肝毒性的有效治疗药物。
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| 关 键 词： | 对乙酰氨基酚肝毒性 代谢损伤 氧化应激 Keap1-Nrf2通路 |
| 收稿时间： | 2011-02-21 |
| 修稿时间： | 2011-02-28 |
Mechanisms of Acetaminophen-induced Hepatotoxicity and Targets for Drug Intervention |
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| WANG Qian,XU Rui-juan and YANG Jin. Mechanisms of Acetaminophen-induced Hepatotoxicity and Targets for Drug Intervention[J]. Pharmacertical and Clinical Research, 2011, 19(3): 247-252 |
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| Authors: | WANG Qian XU Rui-juan YANG Jin |
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| Affiliation: | WANG Qian,XU Rui-juan,YANG Jin* Center of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Because of the wide use of non-steroidal anti-inflammatory drugs acetaminophen,its hepatotoxicity is paid more and more attention.This review introduces its metabolism,disposition in liver and endogenous regulation mechanism related to Keap1-Nrf2 pathway;explains its mechanisms of hepatotoxicity involving two theories: metabolic injury and oxidative stress injury.Important of all,we focus on its intervention targets related to absorption,metabolism and transport of drugs.Recent studies are interested in the... |
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| Keywords: | Acetaminophen hepatotoxicity Metabolic injury Oxidative stress Keap1-Nrf2 pathway |
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