紫杉醇联合奈达铂二线治疗晚期食管癌的临床分析

目的：观察紫杉醇（TAX）联合奈达铂（NDP）二线治疗晚期食管癌的疗效和毒副反应。方法：晚期食管癌26例接受NAP＋TAX联合方案化疗,TAX 75 mg/m2,第1、8天;奈达铂80 mg/m2,第2天。21 d为1个周期,至少治疗2个周期。结果：完全缓解1例,部分缓解10例,稳定9例,进展6例,总有效率为42.3%,中位TTP 4.3个月。主要毒副作用为血液学毒性,Ⅲ＋Ⅳ度白细胞下降、血小板下降分别为26.9%、19.2%,胃肠道、肝、肾毒性轻微,多为Ⅰ~Ⅱ度。结论：紫杉醇联合奈达铂二线治疗晚期食管癌,疗效较好,毒副反应耐受较好,值得扩大样本量来验证是否可以改善患者生存期。

Nedaplatin combined with Pacitaxel in treatment of advanced esophageal carcinoma in second line

Objective: To observe the effects and toxicity of Nedaplatin combined with Pacitaxel of second line chemotherapy in the treatment of advanced esophageal carcinoma.Methods: 26 patients of advanced esophageal carcinoma were treated with Nedaplatin and Pacitaxel combination regimen.Nedaplatin was given at a dose of 80 mg/m2 by intravenous infusion in 1st day,pacitaxol was given at a dose of 75 mg/m2 by intravenous infusion in 1st,8th day,with a course of 21 days for 2 courses at least.Results: The overall resp...