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| 二甲双胍对代谢综合征患者胰岛素抵抗与瘦素水平的影响 | |
| 引用本文： | 钟慧文,郎江明,叶建红,成玲俐. 二甲双胍对代谢综合征患者胰岛素抵抗与瘦素水平的影响[J]. 中国医药导报, 2011, 8(17): 80-81 |
| 作者姓名： | 钟慧文 郎江明 叶建红 成玲俐 |
| 作者单位： | 1. 佛山市禅城区中心医院药剂科,广东佛山,528000 2. 广州中医药大学附属佛山市中医院内分泌科,广东佛山,528000 3. 佛山市南海区盐步医院内科,广东佛山,528000 |
| 基金项目： | 广东省佛山市科技攻关项目 |
| 摘 要： | 目的：探讨二甲双胍对代谢综合征（MS）患者胰岛素抵抗（IR）与瘦素（leptin）水平的影响。方法：根据2005年国际糖尿病联盟关于MS定义的全球共识的标准,选择新诊断MS患者56例,采用病例自身对照方法,给予二甲双胍口服治疗12周,观察治疗前后生化指标、胰岛素抵抗指数（HOMA-IR）、血浆leptin水平变化。结果：治疗12周后,MS患者的体重指数（BMI）、腰围（WC）、空腹胰岛素（FINS）、空腹血糖（FPG）及2 h血糖（2 h PG）明显降低,与治疗前相比均有统计学意义（均P〈0.05）,三酰甘油（TG）、胆固醇（TC）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、SBP及DBP等无显著性变化;MS患者的HOMA-IR显著降低,分别为（3.46±1.59）和（2.00±1.11）,（P〈0.01）;MS患者的血浆leptin水平显著降低,分别为（215.88±89.19）mg/L和（168.45±75.36）mg/L,（P〈0.01）。结论：二甲双胍治疗能改善代谢综合征患者的体重、血糖、血脂等临床指标,改善IR,降低血浆leptin水平，提示二甲双胍改善MS患者胰岛素抵抗的作用可能与leptin抵抗减轻有关。 |
| 关 键 词： | 代谢综合征 二甲双胍 瘦素 胰岛素抵抗 |
Effects of metformin on leptin levels and insulin resistance in patients with metabolic syndrome |
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| ZHONG Huiwen,LANG Jiangming,YE Jianhong,CHENG Lingli. Effects of metformin on leptin levels and insulin resistance in patients with metabolic syndrome[J]. China Medical Herald, 2011, 8(17): 80-81 | |
| Authors: | ZHONG Huiwen LANG Jiangming YE Jianhong CHENG Lingli |
| Affiliation: | ZHONG Huiwen1,LANG Jiangming2,YE Jianhong2,CHENG Lingli3 1.Department of Pharmacy,Chancheng District Hospital in Foshan City,Guangdong Province,Foshan 528000,China,2.Department of Endocrinology,Foshan City TCM Hospital Affiliated of Guangzhou University of Traditional Chinese Medicine,3.Nanhai District Yanbu Hospital in Foshan City |
| Abstract: | Objective: To investigate effects of metformin on leptin levels and insulin resistance in subjects with metabolic syndrome(MS).Methods: 56 subjects aged from 36 to 60 years with MS were selected as MS groups.The diagnostic criteria was according to the recommendation of metabolic syndrome given by IDF in 2005.All subjects received metformin 500 mg every time,3 times every day for 12 weeks.Before and after treatment,insulin resistance were calculated by way of HOMR-IR and blood leptin levels were measured by... |
| Keywords: | Metabolic syndrome Metformin Leptin Insulin resistance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |