三七总皂甙及三七皂甙C_1对实验动物血糖的影响

三七Panax notoginseng(Burk)F.H.Chen]系五加科人参属植物,药用其根。中医用于活血、止痛、止血、散瘀、消肿等。三七皂甙为其主要有效成分。1937年朱任宏由三七分离得两种皂甙,分别水解后得三七皂甙元A及三七皂甙元B。1941年许植方由云南三七得

EFFECTS OF GENERAL SAPONIN OF PANAX NOTOGINSENG AND SANCHINOSIDE C_1 ON BLOOD SUGAR IN EXPERIMENTAL ANIMALS

General saponin is the major effective substance in the fibrous root of Panax notoginseng (Burk) F. H. Chen, and sanchinoside C_1 is the main constitueet of this general saponin. Their effects on blood sugar were Studied on experimental animals. It was found that oral administration of sanehinoside C_1 in mice, was followed, by a slight rise in fasting blood sugar and a fall to normal level in hyperglycemia. But sanchinoside C_1 showed no influence on hyperglycemia induced by adrenalin.General saponin of Panax notoginseng can also raise the fasting blood sugar level in mice and decreases the hyperglycemia in mice and rabbits, but it did not influence on the ability of insulin in reducing blood sugarln rabbits. The effect of this general saporiin differs from sanchinoside C_1 in that the latter increases hyperglycemia induced by adrenalin in mice and rabbits.