Diffusion transport in interpolyelectrolyte matrix systems based on chitosan and Eudragit L100 |
| |
| Authors: | R. I. Mustafin A. A. Protasova G. Van den Mooter V. A. Kemenova |
| |
| Affiliation: | (1) Kazan Medical University, Kazan, Tatarstan, Russia;(2) Leuven Catholic University, Leuven, Belgium;(3) All-Russia Institute of Medicinal and Aromatic Plants, Scientific Center for Biomedical Technologies, Moscow, Russia |
| |
| Abstract: | With a view to the development of new controlled drug delivery systems, the formation of an interpolyelectrolyte complex (IPEC) between chitosan (CTS) and Eudragit L100 (L-100) has been studied. The structure of this IPEC is such that two maxima are observed in the curves of IPEC swelling in the media with different pH values. The release of a model drug (ibuprofen) from IPEC-based tablets is significantly retarded, and this delay can be controlled by changing the molecular weight of CTS in the IPEC composition. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 44–46, December, 2005. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
