Long-term immunogenicity of influenza vaccine among the elderly: Risk factors for poor immune response and persistence |
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Authors: | Joon Young Song Hee Jin Cheong In Sook Hwang Won Suk Choi Yu Mi Jo Dae Won Park Geum Joo Cho Taik Gun Hwang Woo Joo Kim |
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Institution: | 1. Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea;2. Guro-gu Public Health Center, Seoul, Republic of Korea |
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Abstract: | The elderly have been considered as the priority group for influenza vaccination, but their influenza vaccine-induced antibody was believed to decline more rapidly. Long-term immunogenicity of the influenza vaccine among the elderly was evaluated as compared to young adults. Serum hemagglutinin inhibition (HI) titers were determined at pre- and post-vaccination periods (at 1, 6, and 12 months after vaccination). Of the 1018 subjects, 716 (70.3%) were followed up during a 12-month period. Seroprotection rates at 1 month post-vaccination ranged from 70.1% to 90.3% depending on the age group and influenza vaccine virus strain. At 6 months post-vaccination, seroprotection rates for all three strains had declined significantly in adults ≥65 years (P < 0.01), but still met the EMEA criteria. Low pre-vaccination HI titer (<1:40) and advanced age were associated with early decline of HI titers, falling below seroprotective levels around 6 months after vaccination. |
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Keywords: | Influenza Vaccination Elderly Immunogenicity |
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