Evaluating the Brighton Collaboration case definitions,aseptic meningitis,encephalitis, myelitis,and acute disseminated encephalomyelitis,by systematic analysis of 255 clinical cases |
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| Authors: | Barbara Rath Manya Magnus Ulrich Heininger |
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| Affiliation: | 1. Charité University Medicine, Department of Pediatrics, Berlin, Germany;2. Department of Epidemiology and Biostatistics, The George Washington University School of Public Health and Health Services, Washington, DC, USA;3. Infectious Diseases and Vaccines, University Children''s Hospital Basel, Basel, Switzerland |
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| Abstract: | AimsBrighton Collaboration (BC) case definitions are independent from presumed causes or triggers, hence should be applicable in routine clinical settings.Scope255 cases with discharge diagnoses of aseptic meningitis (ASM; n = 164), encephalitis (ENC; n = 48), myelitis (MYE; n = 8), ADEM (n = 10), or bacterial meningitis (BM; n = 59; control group) were tested against the BC case definitions ASM, ENC, MYE, and ADEM. Overall rates of agreement between BC criteria and discharge diagnoses were 70%, 78%, 97%, and 97% for ASM, ENC, MYE and ADEM, respectively.ConclusionBC case definitions are easily applicable in retrospective chart reviews allowing causality assessments with minimal selection bias. |
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| Keywords: | AEFI, adverse events following immunization ADEM, acute disseminated encephalomyelitis ASM, aseptic meningitis MYE, myelitis ENC, encephalitis BM, bacterial meningitis |
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