Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures |
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Authors: | Marc P Hübner Marina N TorreroEdward Mitre |
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Institution: | Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA |
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Abstract: | Animal studies have demonstrated that helminth vaccines which induce type 2 immune responses can be protective. To date, however, such vaccines have not been tested against repeated parasite challenges. Since repeated antigenic challenge of patients with allergic disease results in immunologic tolerance, we hypothesized that a helminth vaccine which induces type 2 immune responses may lose its protective efficacy in the setting of repeated parasite exposures (RPEs). To test this hypothesis, we examined whether RPEs induce immunological tolerance and reduce the effectiveness of a type 2 immune-inducing vaccine. BALB/c mice vaccinated against Litomosoides sigmodontis, a filarial nematode of rodents, were repeatedly exposed to irradiated larvae for 2 or 8 weeks or to non-irradiated infectious larvae for three months. |
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Keywords: | Vaccine Helminth IgE Type 2 immunity IL-4 Basophil Filaria Litomosoides sigmodontis Immunological tolerance Desensitization Regulatory T-cells |
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