Cognitive factors and willingness to participate in an HIV vaccine trial among HIV-negative injection drug users |
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| Authors: | Shayesta Dhalla Gary Poole Joel Singer David M. Patrick Evan Wood Thomas Kerr |
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| Affiliation: | 1. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada;2. Canadian HIV Trials Network, St. Paul''s Hospital, Vancouver, BC, Canada;3. BC Centre for Disease Control, Vancouver, BC, Canada;4. BC Centre for Excellence in HIV/AIDS, St. Paul''s Hospital, Vancouver, BC, Canada;5. Division of AIDS, Department of Medicine, University of British Columbia, Vancouver, BC, Canada |
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| Abstract: | This cross-sectional study involving a cohort of injection drug users (IDU) examined the relationship between cognitive factors (HIV treatment optimism, self-efficacy and knowledge of vaccine trial concepts) as well as risk factors for seroconversion, and willingness to participate (WTP) in a preventive phase 3 HIV vaccine trial. Willingness to participate overall was 56%. In a multivariate analysis, for a 20-unit increase in a 100-point composite scale, self-efficacy was positively related to WTP (adjusted odds ratio [AOR] = 1.95, 95% CI = 1.40–2.70). HIV treatment optimism and knowledge of vaccine trial concepts were unrelated to WTP. Aboriginal ethnicity (AOR = 3.47, 95% CI = 1.68–7.18) and a higher educational level (≥high school) (AOR = 1.96, 95% CI = 1.07–3.59) were positively related to WTP. This study provides information on WTP for an HIV vaccine trial. Limitations and future directions are also discussed. |
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| Keywords: | HIV vaccine preparedness Cognitive factors Injection drug users VIDUS Vancouver |
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