Differential activation of host cell signalling pathways through infection with two variants of influenza A/Puerto Rico/8/34 (H1N1) in MDCK cells |
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| Authors: | B Heynisch T Frensing K Heinze C Seitz Y Genzel U Reichl |
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| Institution: | 1. Chair of Bioprocess Engineering, Institute for Process Engineering, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany;2. Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Germany |
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| Abstract: | In cell culture-based influenza vaccine production, few efforts have been undertaken to characterise virus–host cell interactions in detail. Two influenza virus strains that grew to different virus titres, and differed in virus dynamics, apoptosis induction and proteome changes were observed. |
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