| 鱼藤酮帕金森病大鼠模型建立的研究 |
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| 引用本文： | 冯媛,梁直厚,王涛,乔娴,孙莉,刘红进,孙圣刚.鱼藤酮帕金森病大鼠模型建立的研究[J].卒中与神经疾病,2004,11(6):374-377. |
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| 作者姓名： | 冯媛 梁直厚 王涛 乔娴 孙莉 刘红进 孙圣刚 |
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| 作者单位： | 430022,武汉,华中科技大学同济医学院附属协和医院神经内科 |
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| 摘 要： | 目的探讨鱼藤酮帕金森病大鼠模型的建立方法.方法采用背部皮下注射鱼藤酮,然后观察大鼠的行为学及黑质-纹状体的酪氨酸羟化酶免疫活性变化、海马病理学变化.结果经过1～8周观察,鱼藤酮处理大鼠出现明显的行为学、黑质-纹状体酪氨酸羟化酶免疫活性变化,海马无明显病理学变化,模型显示出帕金森病的典型特征.结论背部皮下注射鱼藤酮的方法可成功制作帕金森病大鼠模型.
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| 关 键 词： | 鱼藤酮 帕金森病 动物模型 |
| 文章编号： | 1007-0478(2004)06-0374-04 |
The parkinson disease model induced by rotenone in rats |
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| Abstract: | Objective To explore the method of reproducing Parkinson disease model in rats.Methods The rotenone was injected subcutaneously to the back of rats.Then,the behaviors features,the tyrosine hydroxylase immunoreactivity in substantia nigra and corpora striata,and HE pathology in hippocampus were observed.Results The rotenone causes rats with behaviors features of Parkinson disease,reduced the tyrosine hydroxylase immunoreactivity in subtantia nigra and corpora striata,but not to reduce the cells in hippocampus during 1 8weeks.Conclusion Rotenone injected subcutaneously in back is an effective method to reproduce the Parkinson disease model in rats. |
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| Keywords: | Rotenone Parkinson disease Animal model |
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