蛛网膜下腔出血后脑血管痉挛患者血清C反应蛋白的变化及临床意义

目的观察蛛网膜下腔出血(SAH)患者的C反应蛋白(CRP)的变化,探讨C反应蛋白在SAH及并发脑血管痉挛(CVS)中的临床意义。方法将19例急性SAH患者分为CVS组(9例)和非CVS(10)组,测量两组患者第3、7、14天的CRP。结果CVS组和非CVS组在发病后第3、7和14天的CRP水平明显升高(P<0.01);CVS组在第7天的CRP水平明显高于第3天,而非CVS组中CRP水平在第7天和第14天明显低于第3天(P<0.01);CVS组在第3天、第7天和第14天的CRP水平也明显高于非CVS组同期水平(分别为P<0.05、P<0.01、P<0.01)。结论CRP对于病情的监测和预后具有重要作用。

Variation of serum C-reactive protein (CRP) level and its clinical significance in patients with cerebral vasospasm following subarachnoid hemorrhage

Objective To investigate changes of serum C-reactive protein(CRP) level and its clinical significance in patients with cerebral vasospasm(CVS) following subarachnoid Hemorrhage(SAH).Methods Nineteen patients with acute SAH were divided into 2 groups: CVS group(n=9) and no-CVS group(n=10).Serum CRP level was measured on day 3,7 and 14.Results CRP levels on days 3,7 and 14 were significantly elevated in both groups compared respectively with their baseline level(P<0.01).In CVS group,CRP level on day 7 was higher than on day 3;in no-CVS group,CRP levels on day 7 and 14 were lower than on day 3(P<0.01).CRP level in CVS group were always higher than in no-CVS group on day 3,7 or day 14(P<0.05,P<0.01 and P<0.01,respectively).Conclusions Measurement of serum CRP level is very useful to judge the presence of CVS following SAH.