| 吸烟对家兔巨噬细胞溶酶体酸性磷酸酶的影响 |
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| 引用本文： | 朱金元,皇甫梅生.吸烟对家兔巨噬细胞溶酶体酸性磷酸酶的影响[J].温州医学院学报,1988(4). |
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| 作者姓名： | 朱金元 皇甫梅生 |
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| 作者单位： | 温州医学院组胚教研组
(朱金元)，温州医学院生化教研组(皇甫梅生) |
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| 摘 要： | 本文通过体内外实验观察了吸烟对家兔肺巨噬细胞溶酶体酸性磷酸酶的影响。结果表明:体外香烟烟雾凝聚物具有直接抑制肺巨噬细胞溶酶体酸性磷酸酶活性的作用(1mg组P<0.01),而慢性香烟烟雾吸入会导致肺巨噬细胞溶酶体酸性磷酸酶活性的升高(P<0.01)。溶酶体酸性磷酸酶释放的明显增加是引起肺损伤导致肺气肿的重要环节。
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| 关 键 词： | 吸烟 肺巨噬细胞 溶酶体 酸性磷酸酶 |
EFFECT OF SMOKING ON LYSOSOMAL ACID PHOSPHATASE OF THE RABBIT PULMONARY MACROPHAGES |
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| Zhu,Jinyuan.EFFECT OF SMOKING ON LYSOSOMAL ACID PHOSPHATASE OF THE RABBIT PULMONARY MACROPHAGES[J].Journal of Wenzhou Medical College,1988(4). |
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| Authors: | Zhu Jinyuan |
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| Institution: | Zhu Jinyuan ( Department of Histology & Embryology )
Huangpu Meisheng ( Department of Biochemistry ) |
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| Abstract: | The effect of smoking in vivo and in vitro on lysosomal acid phosphatase of the rabbit pulmonary macrophages was studied. The results showed that the smoke condensates appeared directly to inhibit the activity of lysosomal acid phosphatase of the pulmonary macrophage (1 mg group, P<0.01) and the chronic smoke inhalation might enhance the activity of lysosomal acid phosphatase of the pulmonary macrophage ( P<0.01 ) , Furthermore, the marked increases of the release of lysosomal enzymes might be important mediators of pulmonary damage leading to pulmonary emphysema. |
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| Keywords: | Smoking pulmonary macrophages lysosomal Acid phesphatase |
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