| 注射用葫芦素B自微乳化药物传递系统的处方优化 |
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| 引用本文： | 李墨,赵秀丽,陈大为,杨云云.注射用葫芦素B自微乳化药物传递系统的处方优化[J].沈阳药科大学学报,2008,25(1):15-19. |
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| 作者姓名： | 李墨 赵秀丽 陈大为 杨云云 |
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| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的对注射用葫芦素B自微乳化药物传递系统进行处方优化。方法在注射级辅料中筛选油相、乳化剂和助乳化剂,根据空白假三元相图和粒径分析进一步优化处方。结果最佳处方组成为m(油酸乙酯)∶m(Cremophor RH)∶m(乙醇)=30∶55∶15,其中药物含量的质量分数为1%。结论可按照最佳处方组成制备注射用葫芦素B自微乳化药物传递系统。
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| 关 键 词： | 葫芦素B 自微乳化药物传递系统 处方优化 假三元相图 |
| 文章编号： | 1006-2858（2008）01-0015-05 |
| 收稿时间： | 2007-04-16 |
| 修稿时间： | 2007年4月16日 |
Formulation optimization of cucurbitacin B self-emulsifying drug delivery system for injection |
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| LI Mo,ZHAO Xi-uli,CHEN Da-wei,YANG Yun-yun.Formulation optimization of cucurbitacin B self-emulsifying drug delivery system for injection[J].Journal of Shenyang Pharmaceutical University,2008,25(1):15-19. |
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| Authors: | LI Mo ZHAO Xi-uli CHEN Da-wei YANG Yun-yun |
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| Institution: | School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China |
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| Abstract: | Objective To search for the optimum formulation for the self- microemulsifying drug delivery system of cucurbitacin B. Methods The oils,emulsifiers and co-emulsifiers from adjuncts for injection were screened, the pseudo-ternary phase diagram of blank self-microemulsifying drug delivery system was drawn and particle size was analyzed to determine the optimum formulation. Results The constitution of optimum formulation was as follows: m(Ethyl oleate) : m(Cremophor RH) : m(Ethanol) =30∶55∶15. Conclusion Self-microemulsifying drug delivery system of cucurbitacin B can be prepared according to the optimum formulation. |
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| Keywords: | cucurbitacin B self-microemulsifying drug delivery system(SMEDDS) formula optimization pseudo-ternary phase diagrams |
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