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注射用葫芦素B自微乳化药物传递系统的处方优化
引用本文:李墨,赵秀丽,陈大为,杨云云.注射用葫芦素B自微乳化药物传递系统的处方优化[J].沈阳药科大学学报,2008,25(1):15-19.
作者姓名:李墨  赵秀丽  陈大为  杨云云
作者单位:沈阳药科大学,药学院,辽宁,沈阳,110016
摘    要:目的对注射用葫芦素B自微乳化药物传递系统进行处方优化。方法在注射级辅料中筛选油相、乳化剂和助乳化剂,根据空白假三元相图和粒径分析进一步优化处方。结果最佳处方组成为m(油酸乙酯)∶m(Cremophor RH)∶m(乙醇)=30∶55∶15,其中药物含量的质量分数为1%。结论可按照最佳处方组成制备注射用葫芦素B自微乳化药物传递系统。

关 键 词:葫芦素B  自微乳化药物传递系统  处方优化  假三元相图
文章编号:1006-2858(2008)01-0015-05
收稿时间:2007-04-16
修稿时间:2007年4月16日

Formulation optimization of cucurbitacin B self-emulsifying drug delivery system for injection
LI Mo,ZHAO Xi-uli,CHEN Da-wei,YANG Yun-yun.Formulation optimization of cucurbitacin B self-emulsifying drug delivery system for injection[J].Journal of Shenyang Pharmaceutical University,2008,25(1):15-19.
Authors:LI Mo  ZHAO Xi-uli  CHEN Da-wei  YANG Yun-yun
Institution:School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China
Abstract:Objective To search for the optimum formulation for the self- microemulsifying drug delivery system of cucurbitacin B. Methods The oils,emulsifiers and co-emulsifiers from adjuncts for injection were screened, the pseudo-ternary phase diagram of blank self-microemulsifying drug delivery system was drawn and particle size was analyzed to determine the optimum formulation. Results The constitution of optimum formulation was as follows: m(Ethyl oleate) : m(Cremophor RH) : m(Ethanol) =30∶55∶15. Conclusion Self-microemulsifying drug delivery system of cucurbitacin B can be prepared according to the optimum formulation.
Keywords:cucurbitacin B  self-microemulsifying drug delivery system(SMEDDS)  formula optimization  pseudo-ternary phase diagrams
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