经方补阳还五汤对神经功能缺失影响的一种药理学评价方法

目的：观察补阳还五汤对脑梗死动物模型大鼠神经损伤严重度评分（NSS）的影响。方法：采用线栓法复制大脑中动脉梗死动物模型,实验动物随机分为模型组、补阳还五汤组,每组10只,另取10只同批次的动物作为空白对照组。在造模2周后开始给药,共给药6周。并在给药前,给药后2、4、6周进行神经损伤严重度评分。结果：动物造模后出现一侧的感觉、运动、反射等神经功能障碍,造模动物（模型组、补阳还五汤组）NSS评分下降（与空白组比较P〈0·01）,并随时间发展,有一定的恢复（模型组各时点比较P〈0·01）。补阳还五汤能促进神经缺失的康复（与模型组各时点比较,P〈0·01或〈0·05）。结论：补阳还五汤具有改善脑梗死模型大鼠神经损伤严重度评分的作用。

A pharmacology method to estimate effect of Buyang Huanwu Decoction on neurologic deficits of MCAo Model Rat

Objective：To observe effect of Buyang huanwu Decoction on Neurological Severity Score（NSS） of MCAo model rat.Methods：MCAo rat models were reproduced by Intraluminal Suture.Twenty survivals were classified into two groups after 2 weeks：model group （n=10） and Buyang Huanwu Decoction group （n=10）,in comparison with other ten normal rats.Each rat was scored by NSS at baseline,week2,week4,and week6.Results：Model rats showed neurologic deficits and decreased NSS scores compared with normal rats （P0·01）.The neurologic deficits showed certain degree of spontaneous recovery.The score of Buyang Huanwu Decoction group were significantly higher than those of model group at different time points （P0·01 orP0·05）.Conclusion：Buyang Huanwu Decoction can improve Neurological Severity Score in MCAo model rats.