海南地区原发性肝癌与HBV感染关系的探讨

对 771例原发性肝癌患者及同期 794例其他消化道恶性肿瘤患者的血清HBV标记进行回顾性对比分析。结果发现肝癌组HBVM阳性 72 6例 (94 16 % ) ,非肝癌组HBVM阳性 138例 (17 38% ) ,有显著差异 (P <0 0 1)。在感染HBV模式中 ,肝癌组HBVM以“小三阳”为主 ,占全部肝癌患者的 6 7 0 6 % (5 17/ 771) ,明显高于非肝癌组的 13 4 8% (10 7/ 794 ) ,“小三阳”中HBVDNA阳性明显高于其他HBVM阳性模式组。说明原发性肝癌的发生与HBV有着非常密切的关系 ,而HBV与肝细胞的整合及不同的HBV基因型可能是其发生癌变的重要病理生理学基础

The correlation between primary hepatic carcinoma and HBV infection

To explore the correlation between primary hepatic carcinoma(HCC) and HBV infection, we retrospectively analyzed HBV sero-markers in 771 patients with HCC and 794 patients with other malignant digestive tracts tumours. The results showed the positive rate of HBVM was 94.16% in HCC group (726/771) while 17.38% in other malignant digestive tracts tumours (138/794) (P<0.01). In HBVM modes. mode HBsAg ,HBeAb ,HBcAb was 67.06%(517/771)which is main mode in HCC group and 13.48%(107/794) in non HCC group. HBV DNA positive rate in mode HBsAg ,HBeAb ,HBcAb is significantly higher than those in other modes. The results suggested that there is closely correlation between HCC and HBV infection. The integration of HBV DNA into the host liver cells and different HBV genotypes may be important factors in the pathogenesis of HCC.