Sequence of a novel HLA-A*0301 intronic variant (A*03010103) |
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| Authors: | Mayor N P Cox S T McWhinnie A J Argüello J R Shaw B E Little A-M Madrigal J A Marsh S G E |
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| Affiliation: | The Anthony Nolan Research Institute, The Royal Free Hospital, Hampstead, London, UK. |
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| Abstract: | We report here the full-length sequence of a novel HLA-A*0301 allele, A*03010103, which differs from A*03010101 by a single nucleotide substitution (G>T) at position 492 within intron 2. The variant was originally identified by Reference Strand-mediated Conformational Analysis (RSCA) and was confirmed by cloning and sequencing. The difference in RSCA mobility between A*03010101 and A*03010103 demonstrates the sensitivity of RSCA to detect single nucleotide polymorphisms. |
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| Keywords: | A*03010103 HLA intron variant RSCA |
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