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| 前列腺癌患者外周血HGF检测及其临床意义 | |
| 引用本文： | 刘润花,赵富玺,郭俊成. 前列腺癌患者外周血HGF检测及其临床意义[J]. 临床和实验医学杂志, 2010, 9(6): 417-418 |
| 作者姓名： | 刘润花 赵富玺 郭俊成 |
| 作者单位： | 1. 山西大同大学医学院外科研究室,山西,大同,037009 2. 山西大同大学,山西,大同,037009 3. 山西大同大学医学院免疫学研究所,山西,大同,037009 |
| 摘 要： | 目的检测前列腺癌患者外周血中肝细胞生长因子（HGF）的表达水平，评价HGF对前列腺癌早期诊断的价值。方法采用酶联免疫吸附法对27例原位前列腺癌、20例远处转移前列腺癌患者以及15例前列腺正常者外周血HGF的表达水平进行检测。结果前列腺原位癌及转移癌患者血清HGF的表达水平均明显高于正常对照组（P〈0．0001），分别为823．5±262．8pg／ml、1260．0±641．8pg／ml和405．3±129．4pg／ml。转移癌组又明显高于原位癌组（P〈0．002）。HGF在转移癌组的灵敏度要高于原位癌，分别为100％和70．4％，特异度均为93．3％。结论HGF可作为前列腺癌的早期血清学诊断指标。 |
| 关 键 词： | 肝细胞生长因子 前列腺癌 诊断 |
Serum levels of hepatocyte growth factor in patients with prostate cancer |
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| LIU Run-hua,ZHAO Fu-xi,GUO Jun-cheng. Serum levels of hepatocyte growth factor in patients with prostate cancer[J]. Journal of Clinical and Experimental Medicine, 2010, 9(6): 417-418 | |
| Authors: | LIU Run-hua ZHAO Fu-xi GUO Jun-cheng |
| Affiliation: | LIU Run-hua,ZHAO Fu-xi,GUO Jun-cheng. The Department ofMedicine,Shanxi Datong University,Datong Shanxi037009,China. |
| Abstract: | Objective To investigate the serum levels of hepatocyte growth factor (HGF) in patients with prostate diseases, and evaluate its significance for diagnosing prostate cancer.Methods The serum levels of HGF in 62 patients were detected by ELISA, 27 localized prostate cancer, 20 metastatic prostate cancer, and 15 apparently healthy men as acontrol group were included in this study.Results Serumlevels of HGF were significantly higher in patients with localized prostate cancer and metastatic prostate cancer, com... |
| Keywords: | Hepatocyte growth factor (HGF) Prostate cancer Diagnosis |
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