Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis |
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Authors: | Beyeler C; Frey BM; Bird HA |
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Institution: | Department of Rheumatology, CH-3010 Berne, Switzerland. |
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Abstract: | The objective was to analyse whether the activity of the cytochrome P450
isoenzyme CYP3A4 is altered by disease activity of rheumatoid arthritis
(RA). Urinary 6 beta-hydroxycortisol excretion, expressed as a fraction of
the urinary creatinine output, was measured in 21 patients with RA treated
with three different disease-modifying anti- rheumatic drugs (DMARDs) over
24 weeks. There were no correlations between urinary 6
beta-hydroxycortisol/creatinine (6 beta-OHC/Creat) ratio and measurements
of disease activity such as plasma viscosity, Ritchie articular index and
early morning stiffness. In addition, the three DMARDs sulphasalazine,
sodium aurothiomalate and D-penicillamine, smoking and the intake of
various CYP3A4 substrates had no consistent detectable effect on the 6
beta-OHC/Creat ratio. There is no evidence that the dosage of drugs
metabolized by the CYP3A4 isoenzyme needs to be adjusted for disease
activity in RA.
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