复方甘草酸苷注射液相关视乳头水肿

32岁男性患者,因慢性乙型肝炎静脉给予复方甘草酸苷注射液40ml加入0.9%氯化钠注射液100ml,1次/d,静脉滴注,共11d,后增加剂量至复方甘草酸苷注射液100ml加入0.9%氯化钠注射液250ml,1次/d,共7d。患者每天在输液过程中均出现头晕、眼胀、轻度视物模糊。停药后视物模糊仍再加重。眼科检查:双眼视乳头水肿,隆起1D,视盘边界不清,有轻微出血。BP90/70mmHg。给予患者维生素B1等药物治疗,数日后患者视乳头水肿有所消退,但视物模糊未改善。

Papilloedema associated with by compound glycyrrhizin injection

A 32-year-old man with chronic viral hepatitis B was administered with 40 ml of compound glycyrrhizin injection mixed with 100 ml of sodium chloride injection 0.9% once daily by intravenous infusion for 11 days.And then the dosage of compound glycyrrhizin injection was increased to 100 ml mixed with 250 ml of sodium chloride injection 0.9% once daily for 7 days.The patient developed dizzy,eyes distending,mild blurred vision during intravenous infusion every day.Despite discontinuation of the drug,his blurred vision was aggravated.Ophthalmological examination revealed bilateral papilloedema,swelling 1 D,blurring of the optic disc margins with minor bleeding.The patient's BP was 90/70 mmHg.Then he was treated with vitamin B1 and other medicines.A few days later,his papilloedema subsided,but his blurred vision did not improve.