| 多囊卵巢综合征卵巢颗粒细胞凋亡研究进展 |
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| 引用本文： | 李慧蓉,魏兆莲. 多囊卵巢综合征卵巢颗粒细胞凋亡研究进展[J]. 国外医学(计划生育．生殖健康分册), 2009, 0(5): 331-333,340 |
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| 作者姓名： | 李慧蓉 魏兆莲 |
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| 作者单位： | 安徽医科大学第一附属医院生殖中心,合肥230022 |
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| 摘 要： | 多囊卵巢综合征（PCOS）是一种以内分泌紊乱为主、多种代谢异常导致的异质性临床综合征。PCOS患者双侧卵巢有大量窦卵泡存在，但是不能周期性产生成熟卵泡，其病理机制尚不清楚。目前认为原发性、内在性卵泡生长异常可能是引起PCOS不排卵及临床内分泌改变的病理基础。研究表明，内在性的卵泡发育异常可能与卵巢颗粒细胞的凋亡调控失常有关。通过对PCOS患者卵巢颗粒细胞凋亡的研究，为PCOS病理机制研究提供相关的理论依据，为临床治疗提供新的方向和途径。
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| 关 键 词： | 颗粒细胞 凋亡 多囊卵巢综合征 卵泡 |
Research Progress of Granulosa Cell Apoptosis in Polycystic Ovary Syndrome |
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| LI Hui-rong,WEI Zhao-lian. Reproductive Center of the First Affiliated Hospital of Anhui Medical University,Hefei ,China. Research Progress of Granulosa Cell Apoptosis in Polycystic Ovary Syndrome[J]. , 2009, 0(5): 331-333,340 |
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| Authors: | LI Hui-rong WEI Zhao-lian. Reproductive Center of the First Affiliated Hospital of Anhui Medical University Hefei China |
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| Affiliation: | LI Hui-rong,WEI Zhao-lian. Reproductive Center of the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China |
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| Abstract: | Polycysticovarysyndrome(PCOS)isaheterogeneousclinicalsyndromecausedbymultiplemetabolic abnormalities especially endocrine disorders. A large number of antral follicles are presented in both ovaries of PCOS patients,but mature follicles can't be produced periodically,and its pathological mechanisms are unclear. Present studies suggest that the primary,intrinsic abnormalities of follicular growth might be the pathological basis of anovulation and clinical endocrine disturbance in PCOS. Studies have shown that... |
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| Keywords: | Granulosa cell Apoptosis Polycystic ovarian syndrome Follicle |
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