p-Amino salicylic acid — oxidized cellulose system: a model for long term drug delivery |
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| Authors: | Kiran Bala SK Guha Padma Vasudevan |
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| Institution: | Centre for Bio-Medical Engineering, All India Institute of Medical Sciences & Indian Institute of Technology, New Delhi, India, 110016;Centre for Rural Development and Appropriate Technology, I.I.T. Delhi, New Delhi, India, 110016 |
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| Abstract: | The immobilization of p-amino salicylic acid (PASA) on periodic oxidized cellulose (O.C) as a biocompatible carrier was investigated. The immobilization of the PASA is based on Schiff's base formation between the amino group of PASA and the aldehyde group of O.C. The in vivo and in vitro release of p-amino salicylic acid was studied. Such a system may be useful for the sustained delivery of the drugs in the body, since O.C. itself is a biosoluble carrier. |
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| Keywords: | Cellulose biodegradability drug diffusion oxidation p-amino salicylic acid |
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