原发性皮肤CD30+间变大细胞淋巴瘤6例病理分析

目的探讨原发性皮肤CD30+间变大细胞淋巴瘤(C-ALCL)的临床病理特征、免疫表型及预后,提高对C-ALCL的认识和病理诊断水平。方法对6例C-ALCL进行临床病理分析及免疫组化染色。结果 6例中男性3例,女性3例,中位年龄45岁。以皮肤结节为主要临床表现。组织学上具有间变大细胞淋巴瘤的形态特征,瘤细胞体积大,有明显的多形性和异形性,免疫组化6例瘤细胞弥漫表达CD30+,2例ALK+,3例EMA+,T细胞标记可有CD3、CD4、CD45RO或TIA-1的表达,均不表达CK、CD20、S-100、HMB45。结论 C-ALCL少见,掌握其形态学及免疫组化特点对诊断、鉴别诊断及预后具有重要意义。

Clinicopathologic analysis of primary cutaneous anaplastic large cell lymphoma in 6 cases

Objective To investigate the clinicopathologic features, immunohistochemical findings of primary cutaneous anaplastic large cell lymphoma(C-ALCL). Methods Six cases of C-ALCL were enrolled into the study, the clinicopathologic features, immunohistochemical findings were analyzed. Results There were 3 males and 3 females, median age was 45 years. C-ALCL often presented with solitary skin nodule. Histologically , the lymphoma cells were infiltrated the dermis and subcutis in a sheet-like patter. They were of large size and showed conspicuous nuclear atypia. Immunohistochemical study showed the lymphoma cells were positive for CD30, ALK was noted in 2, and EMA in 3. CD3, CD4, CD45RO or TIA-1 were positive. CD20, S-100, HMB45, CK were negative. Conclusion C-ALCL was rare, it is helpful in diagnosis, differential diagnosis and prognosis for C-ALCL by understanding clinicopathologic and immunophenotypic features.