EGCG对神经病理性疼痛小鼠痛行为学的影响

目的 观察表没食子儿茶素没食子酸酯(EGCG)对神经病理性疼痛小鼠疼痛行为学的影响。方法 ICR小鼠随机分为假手术组、慢性坐骨神经缩窄性损伤组(CCI)、CCI+EGCG 100 mg/kg组、CCI+EGCG 65 mg/kg组、CCI+EGCG 20 mg/kg组,采用Von Frey纤维丝、辐射热测痛仪、冷板法观察EGCG对神经病理性疼痛小鼠疼痛行为学的影响。结果 与CCI组相比,ip给予EGCG 100和65 mg/kg可分别提高小鼠损伤侧后足的机械缩足反射阈值(mechanical withdrawal threshold, PWT)、热缩足反射潜伏期(thermal withdrawal latency, TWL)及冷缩足反射次数(P<0.05)。结论 EGCG可减轻CCI诱发的神经病理性疼痛。

Effects of EGCG on pain behavior of mice with neuropathic pain

Objective To investigated the anti-nociceptive effects of EGCG on neuropathic pain induced by chronic constriction of sciatic nerve injury (CCI) in mice.Methods Establish the models of the chronic constriction injury of sciatic nerve, using the von Frey, plantar, cold-plate, to assess the effect of different doses of EGCG (100, 65, 20 mg/kg) on mechanical, radiant, thermal respectively.Results Compared with CCI group,EGCG of 100, 65 mg/kg could improve the operated lateral paw withdrawal threshold, prolong the operated lateral paw withdrawal latency and reduce the counts of the operated lateral paw withdrawal (P<0.05). Conclusion EGCG can alleviate CCI-induced neuropathic pain.