Syntheses and bioevaluation of substituted dihydropyridines for pregnancy-interceptive activity in hamsters |
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| Authors: | A Mukherjee M S Akhtar V L Sharma M Seth A P Bhaduri A Agnihotri P K Mehrotra V P Kamboj |
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| Institution: | Medicinal Chemistry and Endocrinology Division, Central Drug Research Institute, Lucknow, India. |
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| Abstract: | A number of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-substituted-1,4- dihydropyridines were synthesized and evaluated for pregnancy-interceptive activity in mated hamsters. Out of 24 compounds, 12, 15, 21, 22, 28, and 34 caused a marked reduction in the number of implantations when administered on days 3-8 postcoitum. In an in vitro competition assay, none of the compounds exhibited noticeable binding affinity for uterine progesterone receptors. The results reported here have helped to identify new leads for developing pregnancy-interceptive agents and the active compounds do not seem to elicit their interceptive effect through receptor-mediated inhibition of progesterone action in hamster uterus. |
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