老年男性高血压病患者血清硫酸脱氢表雄酮含量变化的临床意义

目的　观察老年男性原发性高血压患者血清硫酸脱氢表雄酮 (DHEA S)含量变化。方法　用放射免疫法测定 6 2例老年男性高血压病患者血清DHEA S ,并与 35例男性健康老年人对照。结果　高血压病患者血清DHEA S显著降低 ,并随高血压病 1、2、3级逐级递减 ,血压控制不良者低于血压控制良好者 ,病情重组低于病情轻组 ,肥胖者低于体重正常者。多元logistic回归分析显示 ,与DHEA S有独立相关性的因素是年龄、体重、平均动脉压、病情轻重程度及血清胰岛素、C 肽、甘油三酯、载脂蛋白B。结论　高血压病患者血清DHEA S降低 ,并与高血压病某些危险因素如机体老化、肥胖、高胰岛素血症、血清C 肽高值、高甘油三酯血症、血清载脂蛋白B高值及病情加重密切相关

Clinical significance of the change of serum concentration of dehydroepiandrosterone sulfate in elderly men with essential hypertension

Objective To study the change of serum concentration of dehydroepiandrosterone sulfate (DHEA S) in elderly men with essential hypertension.Method Serum DHEA S was measured by radioimmunoassay in 62 elderly men with essential hypertension and 35 healthy elderly men as controls.Results Serum DHEA S in hypertensive group was significantly lower than that in control group, and tended to decrease progressively with increase in grades (grades 1,2,3) of hypertension. It was greatly decreased in the patients whose blood pressure was not controlled at normal range in comparison with that in the patients whose blood pressure was controlled and was markedly decreased in serious hypertension in comparison with that in mild hypertension. Serum DHEA S was markedly decreased in the obese patients in comparison with that in the patients whose body mass index was normal. Multiple logistic regression analysis showed that there were independent correlations between decreased serum DHEA S and progressive increase in age, raised body mass index, increased mean arterial pressure,aggravation of hypertension, and increase in fasting serum insulin, C peptide, triglyceride and apolipoprotein B.Conclusions Serum DHEA S in elderly men with essential hypertension is decreased and is closely correlated with some risk factors such as aging,obesity, hyperinsulinemia,increase in serum C peptide, hypertriglyceridemia,increase in serum apolipoprotein B and aggravation of hypertension.