辅助生殖技术(ART)助孕获得多胎妊娠行减胎术后妊娠结局观察

目的:探讨辅助生殖技术(ART)获得的多胎妊娠孕早期行经阴道减胎术的有效性和安全性。方法:以经ART助孕获得多胎妊娠行经阴道减胎术的患者123例为减胎组,根据减胎后保留的胎儿数分为双胎组(A组,n=90)和单胎组(B组,n=33)。另以同期经ART助孕获得单胎妊娠(C组,n=36)和双胎妊娠(D组,n=57)的患者为对照组。回顾性分析患者的妊娠结局及妊娠期并发症发生情况。结果:减胎组的减胎成功率为100.0%,妊娠成功率为91.9%。A组胎膜早破发生率、早产发生率、新生儿低出生体质量发生率、新生儿重症监护室(NICU)入住率均高于B组(P<0.05)。结论:多胎妊娠孕早期行经阴道减胎术安全、有效、可行。多胎妊娠实施减胎术中减为单胎更为安全。

Observation of Pregnancy Outcomes of Multifetal Pregnancy Reduction by Assisited Reproductive Technology (ART)

Objective: To explore the effectiveness and safety of multifetal pregnancy reduction after assisted reproduction technology(ART).Methods: A total of 123 cases received multifetal pregnancy reduction after ART were retrospectively analyzed.They were divided into twin pregnancies group(group A,n= 90) and single pregnancy group(group B,n=33) according to the number of live fetus after multiple pregnancy reduction.Another 93 pregnancy cases after ART at the same period were set as the control,and were also divided into twin pregnancies group(group C,n=36) and single pregnancy group(group D,n=57).Results: 1) All 123 cases were successful,the successful rate of reduction was 100.0%,the successful rate of pregnancy was 91.9%.2) The rate of premature rupture of membrane,premature delivery,occurence rate of low birth weight and NICU occupancy in group A were higher than those in group B,the difference was statistically significant(P<0.05).Conclusion: 1) Transvaginal ultrasound-guided multifetal pregnancy reduction in the first trimester is a safe,efficient and feasible method after ART.2) It’s much safer to reduce to a singleton in multifetal pregnancy reduction.