子宫内膜容受性的无创性评价

子宫内膜容受性是胚胎着床、成功妊娠的必要条件。对子宫内膜容受性进行评估是辅助生育技术中重要的一环。其评价指标有很多,目前应用较为广泛的包括内膜活检、超声检查、内分泌检查和内膜分泌物分析等。内膜活检法因其创伤性使临床应用受到限制;超声虽能简便有效地预测内膜容受性,但存在很大的争议;激素及分子生物学指标从分子生物学方面阐明了影响内膜容受性的重要因素,具有其独特的临床应用价值;内膜分泌物分析在评价子宫内膜容受性方面,具有无创性、信息量大等优势,近年来正在成为生殖领域研究的热点。

Non-invasive Assessment of Endometrial Receptivity

Endometrial receptivity plays a critical role in embryo implantation and achieving a successful early pregnancy,of which the successful evaluation is the key link of assisted reproductive technology(ART).There are many evaluation indexes for endometrial receptivity including various endomeitrial biopsy,ultrasonic parameters,endocrine examination,analysis of uterine secretions which are widely applied nowadays.Endometrial biopsy is invasive,which clinical application is limited.Ultrasound examination can make an easy and efficient forecast of endometrial receptivity,however,with the more controversy.Hormone traits and molecular biological parameters have unique clinical application values with their elucidation of the important factors affecting endometrial receptivity.Analysis of uterine secretions in the evaluation of endometrial receptivity,with the advantages of non-invasive,large-scale of information,becomes a hot spot in reproductive medicine research in recent years.