脱氢表雄酮(DHEA)预治疗在体外受精-胚胎移植周期中的应用

目的:探讨脱氢表雄酮(DHEA)预治疗在卵巢储备低下妇女的体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)周期治疗中的作用。方法:对173例卵巢储备功能低下进行IVF/ICSI-ET的患者进行随机对照研究。DHEA预治疗组(n=81)患者口服DHEA,连用3个月,对照组为未服用DHEA预治疗者(n=92)。观察患者的一般情况、超促排卵情况及胚胎发育和妊娠结局。结果:患者一般情况、hCG注射日子宫内膜厚度及E2水平、Gn使用量和Gn使用天数组间均无统计学差异(P>0.05)。DHEA组IVF受精率、优质胚胎率及临床妊娠率均高于对照组(P<0.05)。但在胚胎种植率、早期流产率、周期取消率组间差异无统计学意义(P>0.05)。结论:DHEA预治疗可以改善卵巢储备功能低下妇女的IVF结局。

Application of Dehydroepiandrosterone (DHEA) Supplementation in In Vitro Fertilization and Embryo Transfer Cycles

Objective: To investigate the role of dehydroepiandrosterone(DHEA) in women with diminished ovarian reserve(DOR) in IVF/ICSI-ET.Methods: A randomized controlled study was performed on 173 IVF/ICSI cycles of DOR,including 81 cases in DHEA pre-treatment group and 92 cases in control group.General condition of the patients,clinical characteristics embryos development and pregnancy outcomes were compared between the two groups.Results: General condition of the patients,clinical characteristics,endometrial thickness,E2 level on hCG injection day,days of gonadotropin administration,dosage of gonadotropin administration of two groups were not statistically different(P>0.05).Fertilization rate,good-quality embryo rate,clinical pregnancy rate were significantly higher in DHEA group than those in control group(P<0.05).However,there was no significant difference in embryo implantation rate,early abortion rate,cycle cancellation rate in the two groups(P>0.05).Conclusion: DHEA supplementation can improve outcome of IVF in patients with DOR.