行为敏化动物模型在药物依赖性评价中的应用

药物滥用和成瘾呈上升趋势。它既是一个严重的社会问题 ,又是一个非常重要的医学问题。因此 ,对作用于中枢神经系统的药物进行依赖性评价具有十分重要的意义。研究资料表明药物敏化与药物滥用和成瘾具有密切的关系 ,依赖性药物致敏化的药理学特性越来越受到重视。本文介绍了行为敏化动物模型建立的方法 ,阐述了行为敏化形成和表达的神经生物学机制 ,着重探讨了行为敏化动物模型在药物依赖性评价中的作用。

Role of behavioral sensitization animal model in evaluation of drug dependence

Drug abuse and addiction are increasingly severe, which is both a serious social problem and an important medical research work. It is very significant to evaluate dependence potential of centrally acting drugs. Several lines of evidence have shown that there is a close relationship between drug sensitization and drug abuse and addiction. More attention has been directed to sensitization of abused drugs. We introduce the establishment of behavioral sensitization animal model, review neurobiological mechanisms underlying development and expression of behavioral sensitization, and further discuss the role of behavioral sensitization animal model in evaluation of drug dependence.