HLA-B*0749N: the first HLA-B*07 null allele |
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Authors: | Perrier P Dormoy A Proust B Froelich N Bastien A |
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Affiliation: | Laboratoire d'Histocompatibilité, CHU Brabois, 54511 Vandoeuvre-les-Nancy Cedex, France. p.perrier@chu-nancy.fr |
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Abstract: | In the present article, we report the identification of the first HLA-B*07 null allele found in a Polish patient awaiting a kidney allograft. A discrepant result obtained between serological typing (HLA-B "blank") and high-resolution molecular typing using PCR-SSP method (HLA-B*070201 allele) suggested the presence of a null allele. Genomic DNA sequencing of the HLA-B*07 allele revealed a single nucleotide substitution at the 3' end of the exon 4 leading to a premature stop codon. |
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Keywords: | blank allele DNA sequencing gene expression HLA-B antigens HLA-B*0702 |
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