血清TPSA、F/TPSA在前列腺癌诊断中的临床意义

目的探讨血清总前列腺特异抗原(TPSA)、游离前列腺特异抗原(FPSA)检测及其比值(F/T)在前列腺癌诊断中的临床意义。方法用酶联免疫方法检测在我院住院或门诊治疗的137例前列腺癌和前列腺增生患者的TPSA和F/TPSA比值。结果总体比较两组间TPSA及F/TPSA均有统计学意义,在诊断灰区(4ng/ml0.05),而F/T在两组间的差别有统计学意义(P<0.05),在灰区外低值区,TPSA、F/TPSA在两组间的差别均无统计学意义(P>0.05)。结论血清TPSA为前列腺癌的标志物,仍是前列腺癌的主要诊断手段,但F/TPSA值检测能更准确地鉴别位于灰区的前列腺病变性质,在灰区的诊断有重要的意义。

The clinical value of serum total PAS and the ratio of free to total PSA in diagnosis prostatic carcinoma

Objective:To investigate the clinical value of serum total PAS and the ratio of free to total PSA(FT) in differential diagnosis benign prostate hyperplasia(BPH)and prostatic carcinoma(PCa).Methods:Serum FPSA and TPSA were measured in 137 patients with prostate carcimoma(PCa) and benign prostate hyperplasia(BPH) by using enzyne linked immunosorbent assay and the ratio of FPSATPSA was calculated.Results: The comparison of TPSA and FTPSA between total of the two kinds of diseases showed statistical significance.Total PSA,FTPSA were significantly discriminated between PCa and BPH (P<0.01) when the assessed value were much higher beyond gray zone.But the assesses value were within the gray zone,only the comparison of FTPSA showed statistical significance (P<0.05).The assessed value were in lower value range beyond the gray zone, TPSA, FTPSA could not specifically differentiate between the two conditions (both were P>0.05).Conclusion: Serum TPSA is a marker, the determination of TPSA is the important method in diagnosis of prostatic carcinoma,But within gray zone,FTPSA has more important role in discriminating the PCa and BPH.