辛伐他汀对血脂异常人群缺血性脑卒中的预防

目的研究辛伐他汀对血脂异常人群缺血性脑卒中的预防作用。方法将2853例血脂异常人群分为预防组(693例)和对照组(2160例),预防组给予辛伐他汀20mg/d,睡前口服。分析2组血脂变化、心脑血管事件、脑卒中等差异。结果预防组受试者糖尿病患病率比对照组高,预防组随访率98．7%,对照组随访率96．2%。预防组低密度脂蛋白胆固醇较对照组低(2．54±1．01)mmol/L vs(4．12±1．29)mmol/L,P＜0．05],5年生存率高(94．13% vs 83．47%,P＜0．01),缺血性脑卒中和心脑血管事件发生率低。2组死亡的主要原因是:心脑血管疾病、肿瘤和感染。吸烟、高血压、肥胖和糖尿病是脑卒中和心脑血管事件的高危因素。结论辛伐他汀能有效降低血脂异常人群的心脑血管事件。

Prevention of stroke with simvastatin in persons with hypercholesterolemia

Objective To study prospectively the efficacy of simvastatin in prevention of stroke in persons with hypercholesterolemia.Methods 2853 subjects with hypercholesterolemia were divided into simvastatin group (n=693)and control group(n=2160).The subjects in the simvastatin group were treated with 20 mg of simvastatin daily.Admission data,changes of hypercholesterolemia and various events of all subjects were in- vestigated.Statistical analysis was performed using the SPSS statistical package(SPSS).Results There were no significant differences in gender,age,body index,smoking,hypertension between the 2 groups except for more persons with concomitant diabetes mellitus in simvastatin group.Follow-up rate was 98.7% in simvasta- tin group and 96.2% in control group.Compared with control group,simvastatin group showed decrease in low-density lipoprotein cholesterol(LDL-C)levels(2.54±1.01mmol/L vs 4.12±1.29mmol/L,P＜0.05),higher 5-year survival rate(94.13% vs 83.47%,P＜0.01),and lower morbidity of stroke and ves- sel events.Main causes of death were cardio-cerebral vessel diseases,carcinoma,and infections in both groups.Risk factors for stroke and vessel events included smoking,hypertension,obesity,and diabetes melli- tus.Conclusions Simvastatin can decrease significantly the morbidity of cardio-cerebral vessel diseases in persons with hypereholesterolemia.