丹参酮类脂溶性成分及其干预缺血性脑卒中机制的研究进展

缺血性脑卒中是一种由于脑部供血受阻导致缺血灶不可逆损伤的中枢神经系统疾病,其发病突然、传变迅速、病程复杂,静脉溶栓和血管内介入是早期干预的主要措施,但时间窗和禁忌症使其应用受到限制.丹参Salviae Miltiorrhizae Radix et Rhizoma为传统中药材,其中丹参酮类脂溶性成分治疗缺血性脑卒中疗效确...

Research progress on liposoluble constituents of tanshinone and their intervention mechanisms in ischemic stroke

Ischemic stroke is a central nervous system disease that causes irreversible damage to the ischemic focus due to the obstruction of blood supply to the brain. It has a sudden onset, rapid transmission, and complex course. Intravenous thrombolysis and intravascular intervention are the main measures for early intervention. However, the time window and contraindications restrict its application. Danshen (Salviae Miltiorrhizae Radix et Rhizoma) is a traditional Chinese medicine of the motherland. Liposoluble constituents of tanshinone have a definite curative effect in treatment of ischemic stroke and are widely used in clinical practice. The possible mechanisms of tanshinone compounds intervention in ischemic stroke are summarized in this paper, including anti-apoptosis, anti-inflammation, regulating autophagy, limiting glutamate excitotoxicity, inhibiting oxidative stress, promoting neovascularization, etc., in order to provide a certain reference for clinical application.