金栀洁龈含漱液联合米诺环素治疗慢性牙周炎的临床研究

目的 探讨金栀洁龈含漱液联合米诺环素治疗慢性牙周炎的临床疗效.方法 选取2020年3月—2021年8月在新乡医学院第三附属医院收治的122例慢性牙周炎患者,共有患牙183颗,根据随机数字表法将所有患者分为对照组和治疗组,每组各有61例.对照组将盐酸米诺环素软膏注入牙周袋内,略有溢出,1次/周.治疗组在对照组基础上给予金...

Clinical study on Jinzhi Jieying Gargle combined with minocycline in treatment of chronic periodontitis

Objective To investigate the effect of Jinzhi Jieying Gargle combined with Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods Patients (122 cases, 183 teeth) with chronic periodontitis in the Third Affiliated Hospital of Xinxiang Medical University from March 2020 to August 2021 were randomly divided into control and treatment groups, and each group had 61 cases. Patients in the control group were injected into the periodontal bag with Minocycline Hydrochloride Ointment, and slight overflow, once weekly. Patients in the treatment group were given Jinzhi Jieying Gargle on the basis of the control group, rinsed 10 mL each time for 15 min, six times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes, quality of life, and the levels of PGE₂ and IL-8 in gingival crevicular fluid of two groups were compared. Results After treatment, the total effective rate of the treatment group (86.69%) was significantly higher than that of the control group (70.49%) (P < 0.05). After treatment, the probing depth, gingival index, and plaque index of two groups were significantly decreased (P < 0.05), and the probing depth, gingival index, and plaque index of the treatment group were lower than those of the control group (P< 0.05). After treatment, the OHIP-49 score of two groups was significantly decreased (P < 0.05), and the OHIP-49 score of the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the levels of PGE₂ and IL-8 in gingival crevicular fluid of two groups were significantly lower than those before treatment (P < 0.05). After treatment, the levels of PGE₂ and IL-8 in gingival crevicular fluid of the treatment group were lower than those in the control group (P< 0.05). Conclusion Jinzhi Jieying Gargle combined with minocycline is effective in treatment of chronic periodontitis, which can reduce periodontal symptoms, improve patients'' quality of life, and reduce inflammatory reaction, with good drug safety.